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Aesthetic & Regenerative Endocrinology

Fady Hannah-Shmouni, MD FRCPC

Aesthetic & Regenerative Endocrinology

A Clinician's Pocket Guide — Optimizing the Skin–Endocrine System

$16.99109 pages • PDF • Free sample available
A concise, clinician-focused pocket reference on aesthetic and regenerative endocrinology — optimizing the skin–endocrine system for healthspan. It covers the physiology of endocrine aging, the decline of hormones and peptides across the lifespan, the organs of aging (skin, adipose tissue, and the gut), and evidence-graded interventions: peptides and bioregulators, hormone optimization, supplements and senotherapeutics, and lifestyle and circadian medicine — through to the regenerative frontier of endocrine tissue replacement. Strength-of-evidence ratings, clinical pearls, testing and monitoring references, and citations appear throughout. By Fady Hannah-Shmouni, MD FRCPC — Endocrinologist & Biochemical Geneticist, University of British Columbia; Founder & CEO of Hormonaly.ai. First Edition · 2026 · Hormonaly Press.

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About this pocket guide

Skin is not just a barrier — it is an endocrine organ, both a target and a source of hormonal signaling. Estrogens, androgens, thyroid hormone, cortisol, growth hormone, and insulin all leave visible signatures. You see them in skin quality, healing capacity, hair, and the trajectory of aging.

This pocket reference distills the skin–endocrine system for working clinicians. It covers the physiology, the patterns worth recognizing in an aesthetic consult, and the evidence behind key interventions. Those interventions range from topical retinoids and hormone therapy to regenerative approaches like microneedling, PRP, and peptide-based topicals.

It is deliberately concise: a reference designed to be consulted between patients, with tables and decision points rather than long prose, and citations for every recommendation.

What you'll learn

  • How each major hormone axis (estrogen, androgen, thyroid, cortisol, GH/IGF-1, insulin) manifests in skin and hair
  • Recognizing endocrine patterns in the aesthetic consult — when a cosmetic complaint is a hormonal signal
  • The evidence for hormone-related interventions in skin aging, from topical estrogens to systemic therapy
  • Where regenerative techniques (PRP, microneedling, peptide topicals) have data — and where they don't
  • A practical framework for integrating endocrine assessment into aesthetic practice safely

Who it's for

  • Dermatologists, aesthetic physicians, and nurse injectors who want the endocrine context behind what they see
  • Endocrinologists and primary-care clinicians fielding skin and aging questions
  • Trainees who want a fast, referenced orientation to a genuinely interdisciplinary field

Frequently asked questions

Is this a textbook or a quick reference?

A quick reference. It is formatted as a pocket guide — concise sections, tables, and decision points — meant to be consulted in the flow of clinical work rather than read cover to cover.

Does it cover specific product or brand recommendations?

No. It covers intervention classes and the evidence behind them. Brand selection is left to clinical judgment and local availability.

What's inside

  1. 1Part I · Foundations
  2. 21. What is regenerative endocrinology?
  3. 32. The aging endocrine system
  4. 43. Peptides & bioregulators
  5. 54. Circadian & neuroendocrine timing
  6. 6Part II · The organs of aging
  7. 75. The skin as an endocrine organ
  8. 86. The skin as a neuro-immuno-endocrine organ
  9. 97. The endocrine atlas of skin
  10. 108. The skin–glucocorticoid axis
  11. 119. Estrogen & skin aging
  12. 1210. Endocrine disruptors, clean beauty & the skin
  13. 1311. Adipose tissue as an endocrine organ
  14. 1412. The gut–endocrine axis
  15. 1513. Inflammaging & metabolic aging
  16. 16Part III · Interventions
  17. 1714. Hormone optimization
  18. 1815. Peptides & bioregulators for regeneration
  19. 1916. The gut toolkit
  20. 2017. Supplements & senotherapeutics
  21. 2118. Lifestyle & circadian optimization
  22. 22Part IV · Frontier & practice
  23. 2319. Regenerative organ & tissue replacement
  24. 2420. Putting it together

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